Tramadol hydrochloride tablets help relieve different types of pain. Tramadol is the Generic form of Ultram. ULTRAM ® (tramadol hydrochloride tablets) is a prescription medication indicated for the management of moderate to moderately severe pain. ULTRAM received U.S. Food and Drug Administration (FDA) approval in March, 1995. Tramadol has been prescribed to more than 55 million patients worldwide and ULTRAM has been prescribed to more than 21 million patients in the United States alone.